There is one possible exception. You can be, I think, certain about what you think you are experiencing at this moment. You can be certain that this “experience” does exists, because as you read this you are experience something, otherwise you could not know it. The nature of that something is, of course, uncertain. But it certainly does exist.
Or does it? I would say yes, but you never know. And that is the problem. You never know if some bit of previously unknown data will present itself and change everything we thought we knew.
You just never know.